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by Anthony Roberts - Cialis (Tadalifil citrate),
a phosphodiesterase type 5 inhibitor, is used to
treat erectile dysfunction (ED) and decreased libido
in males. Cialis works by aiding relaxation
of blood vessels and increasing blood flow in the
penis during sexual arousal, resulting in improved
erectile function. Cialis is much longer lasting
than Viagra. Effects can be felt anywhere
between 36-48 hours.
Background
The FDA approved Cialis as a medicine for ED
on November 21, 2003. It is available through prescription
for those who are diagnosed with impotence.
In 1998, ICOS Corporation, and Eli Lilly and Company,
began manufacturing Cialis, which is available orally
in 5mg, 10mg and 20mg tablets. It is also
widely available by many research companies and
underground labs.
Action
Tadalafil improves erectile function significantly,
possibly increase testosterone through increased
sexual activity, and is very safe.
There are limited side effects associated with
its use. The most common side effects are
headache, upset stomach, back pain, and muscle aches,
and usually subside with in a few hours.
Technical Data
In a six month study on men with erectile dysfunction
ranging from mild to severe, 20 mgs of Cialis or
placebo was administered to subjects as needed.
It was discovered that Tadalafil improved ED compared
to placebo. Ability to achieve erection and
sucessful intercourse was 73% greater in those reciving
Cialis verses the placebo group (1). Cialis was
administered three times per week for an extended
period of time, it was found to be extremely safe
and very limited side effects were experienced,
if any (1).
Cialis was also linked to increased testosterone
levels in a one month study where testosterone levels
were found to be significantly higher at the end
of the month, due to increased sexual activity(2).
User Notes
How ironic. Some of the compounds which can be
used to make men more physically attractive to women
(Deca, Tren, etc…) can cause sexual dysfunction.
Even more ironic is that many of the compounds which
make them more attractive to us (Beer, Whiskey,
etc…) can also do this.
Cialis is useful for these occasions…or during
PCT when sexual dysfunction may occur.
Tadalifil citrate is the chemical name
of active ingredient in Cialis. Cialis
is a registered trademark of Lilly ICOS LLC in the
United States and/or other countries.
Cialis Resources
Cialis Prescribing
Information
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| Trivial Name |
Cialis (Tadalifil Citrate) |
| Systematic Name |
(6R-trans)-6- (1,3-benzodioxol-5-yl)-
2,3,
6,7, 12,12a-hexahydro-2- methyl-pyrazino
[1', 2':1,6] pyrido[3,4-b]indole-1,4-dione |
| CAS Number |
171596-29-5 |
| ATC Code |
G04BE08 |
| Merck Index Number |
132854 |
| Chemical Formula |
C22H19N3O4 |
| Molecular Weight |
389.404 g/mol |
| Bioavailability |
16% |
| Metabolism |
Hepatic |
| Elimination Half Life |
17.5 hours |
| Excretion |
Urine |
| Legal Status |
Prescription |
| Route of Administration |
Oral |
References
- A 6-month study of the efficacy and safety
of tadalafil in the treatment of erectile dysfunction:
a randomised, double-blind, parallel-group,
placebo-controlled study in Australian men.
Int J Clin Pract. 2005 Feb;59(2):143-9.
- Type V phosphodiesterase inhibitor treatments
for erectile dysfunction increase testosterone
levels. Clin Endocrinol (Oxf). 2004 Sep;61(3):382-6.
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