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by Anthony Roberts -- One of the first articles I ever wrote
which was widely circulated was about Clenbuterol. I wrote it partially
to clear up some misconceptions about the drug, and partially because I
got tired of answering the same questions over and over. Several years
later, that article has been circulated on almost every anabolic steroid
discussion board on the internet, and those boards who haven’t actually
reposted the article still regularly discuss one of the concepts
pioneered in the article…namely the use of Benadryl with Clenbuterol.
Now, its several years later, and I’ve mostly abandoned Clen for my
own personal use, and actually recommend Albuterol (Salbutamol) as a
much better alternative. Albuterol is a (relatively) selective beta-2
adrenoreceptor agonist, just like Clenbuterol. Honestly, I had pretty
much given up on Clen a couple of years ago because for my own personal
reasons (I had experienced much better results with Ephedrine and
Caffeine). Then, a couple of weeks ago, I tried my first bottle of
Albuterol, mostly out of curiosity…and wow! I like it much more than
Clenbuterol. I mentioned this fact to my research assistant, and she
told me that a lot of figure competitors also prefer Albuterol over
Clenbuterol. I had no idea about that, but based on the effects I had
with Albuterol I can see why. Clen is simply too harsh on most people;
they get too jittery, too shaky, and too anxious. It’s a lot to go
through to burn some fat.
But in my own personal experience, Albuterol produces a much
"cleaner" type of stimulant effect than Clenbuterol. I don’t know how to
really describe this other than to say that the "Clen-shakes" just
aren’t as bad with Albuterol…in addition, I’m able to focus better on my
work when I use Albuterol, while with Clen I’m stimulated but not really
focused.
But even though Albuterol produces a much cleaner stimulant-type
feeling in most people, the main question is "How well does it burn
fat"? As far as fat-burning stimulants go, how does it stack up to
Clenbuterol? Lets face it, most people are really only concerned with
the end results, right? Well, at least in me and the people I’ve worked
with, Albuterol seems to produce significantly better results than Clen
in terms of fat burning effects…and it produces them just a bit more
quickly too. This makes sense, if you think about it. Albuterol is often
thought of as a "shorter acting" version of Clen…and, to draw an
analogy, when we look at the steroids which are shorter acting versions
(think about comparing something like Testosterone Propionate vs./
Cypionate, or NPP vs./ Deca)- they typically produce more dramatic
results a bit quicker than their long acting cousins. I’m finding the
same thing to be true with Albuterol. When we take a look at a medical
study examining Clenbuterol vs. a beta-2 agonist which has an even
longer half life ("Salmeterol"), we see that Clen out performs it in
terms of anabolic effects (1). So I think it would only be logical to
assume that something that was a shorter acting beta-2 agonist than Clen
would likely outperform it, right?
Let me just restate that, to make sure we’re all on the same page,
ok? Clenbuterol outperforms longer acting beta-2 agonists, in terms of
anabolic effects. Albuterol is a beta-2 agonist with a shorter acting
effect than Clenbuterol. Therefore, it’s only logical that Albuterol is
going to be more anabolic than Clen, right? Ok, let’s move on…
To understand how Albuterol works, first we need to take a look at
the Beta adrenergic system. This system is comprised of something called
adrenoreceptors, and the most well known (to bodybuilders anyway) of the
adrenoreceptors are the beta receptors. Beta receptors are embedded in
the cell's outer phospholipid membrane, and are stimulated by all the
really popular stimulants…ephedrine, Clenbuterol, etc... These receptors
can further be divided into three subtypes: 1, 2, & 3, (of which we are
primarily concerned with type-2, because the type-3 variety seems to
primarily be less relevant in humans than in other animals, and because
Albuterol doesn’t stimulate the type-1 receptor). There also exists a
type of receptor known as an alpha receptor, which isn’t relevant here,
but warrants a brief explanation.
Alpha receptors differ from beta receptors in that they are activated
at significantly lower catecholamine levels than are the beta receptors.
A catecholamine is simply an organic compound that affects the
sympathetic nervous system. For example, dopamine, norepinephrine and
epinephrine are all catecholamines.
We are, as I said previously, mostly concerned with Beta-2 receptors,
because those are what we see stimulated with Albuterol. It should come
as no surprise to anyone who has used Clenbuterol as well as Albuterol
is that when you stimulate your beta receptors, it causes something
called vasodilatation (increased blood flow). Stimulation of these
receptors also stimulates the break down of fatty acids into the blood
stream for use as fuel, which causes a reduction in stored fat. Of
course, this increased blood flow also comes with an increased heart
rate.
This explains how Beta-2 adrenergic stimulation can also increase
your body temperature a bit…however this isn’t something that’s too
noticeable on a thermometer…most people will feel a bit hotter, and some
will even break a sweat (I fall into the latter category). Beta-agonists
work to do this by increasing heat production in the cell’s powerhouse,
the mitochondria, which will also increase your basal metabolic rate,
and decrease your appetite. Not too many people feel hungry after a
whopping dose of stimulants.
There is also some evidence that Beta-Agonists are anabolic (more
properly, however, this would actually be anti-catabolic). This is
because Beta-agonists also act to initiate a hormonal cascade that
involves the activation of a compound called cAMP (basically:
cyclic-Adenosine Monophosphate). After this, cAMP activates calpistatin
that is the inhibitor of calpain. Calpain works to degrade protein in
skeletal muscle (among other functions). Therefore, we already saw that
how stimulation of beta 2 receptors have the ability to increase energy
expenditure and free up body fat to be used as fuel, and now we have
some understanding of how that stimulation can also have the potential
to be anti-catabolic as well .
Now that we’re all on the same page regarding the beta-adregenic
system, and what sorts of effects we can expect when we stimulate it
with beta-2 agonists…lets take a more specific look at Albuterol, and
why I think it’s such a great compound.
When we take a look at Albuterol’s ability to burn fat, it’s clear
that it has the ability to aid fat loss in both normal as well as obese
men (2). That’s not very different from Clenbuterol, in any way.
However, in my personal experience with it, I think that Albuterol
really outperforms Clen in areas of strength gains as well as for
athletic purposes….lets take a look at my claim and see how Albuterol
performs in humans…
In one study, subjects were given Albuterol and performed 9 weeks of
isokinetic knee extensions (there was also a group who performed the
same exercise routine but were not given Albuterol). The Albuterol
group, predictably, had better strength gains than the non-Albuterol
group (only a therapeutic dose was given) (3). In my own experience,
strength gains with Albuterol are much better and seen more quickly than
I see them with Clen. In fact, while I don’t particularly experience
much of a performance enhancing effect from Clen in the gym; on the
other hand I see strength gains and muscular improvements within the
first couple weeks of using Albuterol. Of course, this is likely a pure
anabolic effect and probably not easily explained as a simple "enhanced"
anti-catabolic effect, and likely can’t be explained away with the
Calpain idea you read about earlier. I still think that I can take a
pretty good shot at explaining why Albuterol is anabolic, though. strong
body of evidence exists to suggest that Albuterol influences the release
of cAMP. As you may know, cAMP also plays an important role in mediating
certain catecholamines secreted by the adrenal medulla have an
inhibitory effect on muscle dependent protein degradation, but in
addition, norepinephrine released from adrenergic terminals may actually
increase the rate of protein synthesis(not just decrease the rate of
their degradation) in oxidative muscles, thereby leading to increased
protein accretion (representing a true anabolic effect). That’s most
likely the way that we receive part of the anabolic effect from
Beta-stimulation. Another way is perhaps through the beta-adrenergic
stimulated lowering of "Interleukin-6" from fat cells (long story…).
Anecdotally, Clenbuterol and ephedrine have both shown themselves
capable of temporarily increasing strength, and I would bet most
beta-agonists have this effect, but I don’t think has been shown as
conclusively in the medical literature as it has been with Albuterol.
Albuterol has been shown to increase muscle size (3-6) as well as
strength and endurance (3) (*while people have anecdotally reported that
Clen seems to lower their aerobic capacity. Clenbuterol has a
disadvantage when compared with Albuterol in the area of strength gains,
probably due to the act that it use-dependently inhibits action
potential firing in skeletal muscle fibers, which is not
directly caused by inherent Beta-2 stimulant activities (7) . I think
that’s the best quasi-scientific explanation I Again, my own personal
experience and that of my research assistant(s) would also seem to
strongly support this claim…all of us have gotten leaner, bigger and
stronger with the use of Albuterol, while with Clen, we got more ripped
but not really stronger (and certainly not much bigger). Anecdotally,
we’ve seen Clenbuterol fall a bit flat when people use it for anabolic
effects, although in animals it would appear to be highly anabolic,
though human studies are a bit shaky (ha!) in this area.
One of the things I really like about Albuterol is that it has the
potential to actually be used on my cycle to make it safer by improving
my lipid profile (cholesterol)…or during PCT to help get my cholesterol
levels back in check. This is because Albuterol shows significant
benefits to cholesterol as it works to lower total cholesterol,
specifically LDL (the bad stuff) while at the same time elevating HDL
(the good stuff).(8)
In my own particular case, cholesterol never seems to be an issue,
but now that I’m working with Oasis for HRT, it’s certainly in my best
interests to show up every three months with nice looking blood work.
So now is the part you’ve been waiting for (*or the part you skipped
to, ignoring the rest of the article…whatever…). How much of this should
you take, and how often? Well, I can tell you that I have found the best
results by working my way up from 4mgs taken once a day, up to 4-8mgs
taken 3x a day. I know that some people will think that 24ms a day of
this stuff is going to be too much (it is, after all, a stimulant). But
I can tell you that I have a pretty good tolerance for stimulants (I’ve
taken up to 200mcg/day of Clenbuterol, and some other pretty hefty
stimulants that I probably shouldn’t mention in polite company). Most
people are going to find their sweet spot at about 4mgs of Albuterol 3x
a day or so…women will probably take about half that dose, and be fine
with it.
I think that Albuterol is about to become very popular, very soon…and
I, for one, am looking forward to seeing less of my old Clen article
around the ‘net, and more of this one.
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Publication Date:
December 4, 2006
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