MESO-Rx

An investigative series on anti-aging medicine by Brian Alexander of MSNBC is highly critical of the anti-aging industry. Alexander has interviewed a few academics to reinforce the skeptical overview of the industry suggesting the industry is more about financial profiteering than health optimization (”Mainstream docs join anti-aging bandwagon,” April 21).

Dr. Thomas Perls, a Boston University researcher who studies centenarians (people who live at least 100 years), and a vociferous critic of the anti-aging industry, argues that while some anti-aging practitioners “may have their hearts in the right place … in my mind the whole anti-aging practice has so many problems of ethical and professional misconduct. These practices are selling medicines and substances at great profit with very little in the way of clinical studies to support what they are doing.”

Dr. Perls has a long history of trying to discredit the American Academy of Anti-Aging Medicine (A4M) and to eliminate the distribution of human growth hormone for anti-aging purposes that resulted in legal action against Perls by the founders of A4M.

The answers to the science questions can be complicated, but the motivations of some doctors to enter the anti-aging world are not. Dr. Arnold Relman, a former editor of The New England Journal of Medicine who is now a professor emeritus of medicine and social medicine at Harvard Medical School, believes “the interest in anti-aging practice is mainly based on economic considerations” by physicians who are looking to boost income.

Alexander is troubled by the extreme commercialization of the anti-aging industry as seen at anti-aging conventions (”Selling longer life – or snake oil?” April 18).

Indeed, there is no better place to witness the truism of the phrase “hope springs eternal” — and perhaps “there’s a sucker born every minute” — than an anti-aging convention, especially on the trade show floor where the latest products and services are hawked.

At the 15th Annual World Congress on Anti-Aging and Regenerative Biomedical Technologies in Las Vegas, held under the auspices of the American Academy of Anti-Aging Medicine (A4M), dozens of businesses set up displays to market everything from horny goat weed dietary supplements to wands containing dirt that supposedly align water molecules so the H2O will get into your cells…

Dr. Ronald Klatz takes exception to attempts at discrediting the American Academy of Anti-Aging Medicine (A4M) based on vendor booths and dubious products advertised at the convention.

In an interview, Dr. Ronald Klatz, co-founder, with Dr. Bob Goldman, of A4M, said he gets annoyed when reporters wander the booths of an A4M event and use the sketchy claims and flimsy science of fringe products to attack the credibility of A4M or anti-aging in general.

“This exhibit hall is constantly being mistaken for the American Academy of Anti-Aging Medicine,” he said. “But that is just the exhibit hall. That is where advertising, lotions, potions, lasers, X-ray equipment, plastic surgery equipment are being sold. That is an exposition. That is advertising! Then there is the scientific conference. That is where the real science is going on and real clinical medicine is being taught.”

The investigative series reveals that the founders of A4M, Dr. Ronald Klatz and Dr. Bob Goldman, have a conflict of interest with the scientific agenda of A4M since they have financial interests in the very products (e.g. Arasys Perfector) and services (Regenerco) advertised at the associated convention.

But distancing A4M from the kinds of products and services offered at the exposition is somewhat disingenuous. Klatz, Goldman and the company that organizes the meeting itself, Tarsus Group PLC, are deeply involved in some of these same kinds of businesses.

Regenerco, for example, is a Klatz and Goldman company seeking to “offer, at a reasonable cost, high-quality, multi-screened vital pathogen-free stem cells originating from umbilical cords and placentas of healthy, live-births, or autologous [genetically identical] adult stem cells from peripheral blood collection.” It promises to use such cells as an anti-aging therapy and has made a deal with a resort developer in Indonesia, PT Hanno Bali, to be the exclusive stem cell distributor for anti-aging resorts serviced by yet another company called One Life +.

The Arasys Perfector is being funded with up to $500,000 from a firm called CapRegen PLC, a publicly traded regenerative medicine investment company based in the United Kingdom. CapRegen’s founders? Klatz, Goldman and Tarsus Group.

Do the commercial ambitions of the founders of A4M jeopardize the scientific agenda of A4M? What do you think?

A recent ad campaign by Cenegenics Medical Institute seen in various domestic in-flight magazines and on various websites featured the muscular torso of Dr. Jeffry Life, Chief Medical Officer of Cenegenics Las Vegas. One internet banner ad asks the question, “how does this 67-year old doctor have the body of a 30-year old?”

Cenegenics - Muscular Dr. Jeffry Life

The answer, in part, is likely anabolic steroids (testosterone) and human growth hormone which are the cornerstone of anti-aging and age management medicine. The Cenegenics ad campaign seeks to appeal to individuals seeking to improve their physical appearance; benefits may include “improved muscle tone,” “decreased body fat,” “increased energy,” “increased sex drive / libido,” “sharper thinking,” and “improved outlook on life.” These happen to be the same motivations that lead men of all ages to the illicit use anabolic steroids and growth hormone.

When I attended a lecture by Dr. Bob Goldman, American Academy of Anti-Aging Medicine (A4M), at the 2008 Iron Man Expo in Los Angeles, I was surprised that the presentation focused primarily on the obtainability of muscular, athletic physiques through the anti-aging lifestyle with a slideshow featuring several muscular bodybuilders and athletes.

With all the negative news about steroids in baseball and steroid pharmacy scandals, should age management (Cenegenics) and anti-aging organizations (A4M) aggressively market the muscle-building and bodybuilding effects of anabolic steroids (testosterone) and growth hormone (i.e. hormone optimization) to prospective clients? (”Mainstream docs join the anti-aging bandwagon,” April 21)

Now that sports doping scandals have made HGH, as well as testosterone and other hormones, front-page news, and some anti-aging clinics and compounding pharmacies have been raided by the U.S. Drug Enforcement Agency for being overly liberal with hormone prescriptions, the anti-aging community has toned down its endorsement of hormones, at least in public.

“Less than 10 percent of patients involved in anti-aging are receiving growth hormone,” Klatz insists.

That seems a dubious assertion. In fact, hormones remain a key ingredient of anti-aging practice. “Most of my anti-aging patients get hormones,” typically growth hormone as well as sex hormones appropriate to each gender, Jurow says.

Given the steroid hysteria and steroid demonization resulting from the steroids in sports scandals, it seems like this would hurt business for anti-aging medicine. But this has not been the case, business is booming in anti-aging medicine.

Back in 1994, the annual Las Vegas meeting of the fledgling American Academy of Anti-Aging Medicine (A4M) was held in a small hotel off the Las Vegas strip. Everyone could fit into a temporary tent-like structure on the pool patio. Last December, at the 15th A4M confab, roughly 2,000 attendees, including business owners, anti-aging promoters and hundreds of doctors — among them obstetricians, ER docs, psychiatrists and internists — filled a cavernous meeting space inside the Venetian Hotel and Resort.

Today, claims Dr. Bob Goldman, A4M’s co-founder, there are about 20,000 A4M-certified doctors around the world. A4M’s tax returns confirm the boom. The income from fees charged to those seeking board certification from A4M more than doubled from $544,845 in 2005 to $1.2 million in 2006.

A rival organization, Age Management Medicine Group, is growing rapidly, too, says co-founder Rick Merner. He claims the group had more than 400 doctors at its last meeting, sponsored by the nation’s single largest “age-management” clinic, Cenegenics. The Cenegenics Foundation also certifies practitioners in age-management medicine (it shuns the term “anti-aging”) and claims to have experienced a 100 percent increase in the number of its physician “affiliates” to more than 800.

Could the steroid hysteria actually be stimulating business for legal prescriptions for testosterone and growth hormone?! The public condemnation of the muscle-building and performance-enhancing effects of steroids and other PEDs may be accompanied by a private celebration of the potential benefits of these hormones.

Cenegenics